Overview | Understanding the Disorder | Symptoms Diagnosis | Treatment
Image "A"Key Glossary Terms

Reinke’s Edema
“Swelling in Reinke’s space”; a voice disorder caused by accumulation of gelatinous substance in Reinke’s space

Reinke’s Space (Superficial Lamina Propria)
Layer just underneath the surface lining of the vocal fold; composed of cells, special fibers, and other substances (extracellular matrix); has key role in vocal fold vibration

A “radical” surgical procedure that removes (“strips”) the top layers of the vocal folds resulting in severe vocal fold scarring and abnormal voice. Due to the resultant damage, this procedure is at present rarely used


What is Reinke’s edema?
Swelling from Fluid Accumulation in Reinke’s Space
Reinke’s edema is the build-up of a gelatinous substance in the layer right underneath the surface lining of the vocal folds (superficial lamina propria or Reinke’s space). It may occur in one or both vocal folds.
Reinke’s Space Is Not an “Empty Space”
The superficial lamina propria, or Reinke’s space, is not an empty space. It has a defined structure made up of cells, special fibers, and substances made by cells. (For more information, see Anatomy & Physiology of Voice Production.)
The superficial lamina propria (Reinke’s space) plays an important role in the vibration of vocal folds, which is a key element in sound production.

How does Reinke’s Edema affect voice?
Vocal fold vibration is critical for production of sound during speaking or singing. Reinke’s space, or superficial lamina propria, plays a key role in vocal fold vibration. Along with the lining cover, Reinke’s space undergoes a wave-like motion, or “mucosal wave,” during speaking or singing. Any change in shape, volume, flexibility, composition, and/or consistency of this layer results in voice changes.

Voice changes are usually described as: hoarse, raspy, low voice quality, as well as decrease in loudness (volume), and difficulties in how high/low a voice can reach (voice range).
Image blue exclamation pointKey Information
Reinke’s edema is sometimes incorrectly indentified as:

  • Laryngeal polyp
  • Polypoid corditis
  • Vocal fold edema
  • Smoker’s laryngitis
  • Chronic laryngitis

The conditions listed above are distinct and can sometimes present at the same time as Reinke’s Edema.
Careful examination is necessary to arrive at the correct medical diagnosis.

Image Red FlagAdvisory Note

Patient education material presented here does not substitute for medical consultation or examination, nor is this material intended to provide advice on the medical treatment appropriate to any specific circumstances.

All use of this site indicates acceptance of our Terms of Service

Copyright © 2000-2006 Voice Foundation. All rights reserved.