| Abstract | In the rapidly evolving medical landscape, Platelet-Rich Plasma (PRP) therapy has emerged as a promising modality for treating acute and chronic vocal scars, as well as presbyphonia. For many years, these conditions, often challenging to manage with conventional methods, have driven the quest for innovative therapeutic approaches. PRP, enriched with growth factors and cytokines, holds significant promise due to its regenerative potential and tissue healing properties. Building on the findings of the recent study by Woo, which showed significant results, this new paper presents the outcomes of a clinical study aiming to assess the efficacy of this innovative approach.
In this retrospective study, 49 patients with chronic and acute vocal fold or presbyphonia received PRP injections via working channel fibroscopy under local anesthesia. Treatment effectiveness was clinically evaluated one-month post-injection using VHI-30, stroboscopic evaluation, perceptual and acoustical analysis. Additionally, biological characterization of the administered PRP was performed to gain in-depth insights into its components and regenerative potential.
We injected 49 patients, including 30 with chronic scars ( > 6 months), 6 with recent scars ( < 6 months), and 13 with presbylarynges. Out of these cases, 34 patients reported improvement in voice-related complaints, as observed through stroboscopy. Objective acoustic measurements were obtained from 25 patients (pre and post-operative assessments). Although detailed results will be provided, the overall improvement rate was approximately 65%.
Our study revealed substantial improvements among treated patients. Chronic scars exhibited marked reduction, acute lesions displayed accelerated healing, and presbyphonia patients experienced significant enhancement in vocal quality. These findings underscore the clinical efficacy of PRP therapy in these diverse contexts.
Regarding the characterization of the injected product, the average platelet dose administered is 390 million per injection. Furthermore, the measurement of growth factors has deepened the understanding of its underlying regenerative mechanisms.
In conclusion, this study highlights the effectiveness and potential of platelet-rich plasma in the treatment of vocal fold scars and presbyphonia. The encouraging short-term results observed emphasize the growing importance of PRP as an innovative and promising therapy. These findings pave the way for in-depth future research and enhance optimism regarding the expanded clinical application of PRP in the field of regenerative medicine.
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